Bioactive Small Molecules
Medchemexpress LLC 4-CMTB | 300851-67-6 | 99.7% | 294.80 | 25 MG
4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC50=6.38). It acts as both a direct agonist and a positive allosteric modulator of the action of short-chain free fatty acids by modulating the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2). This product is for research use only.
- Functions as a selective FFA2 agonist
- Acts as a positive allosteric modulator
- Modulates FFA2 activity via the FFA2 second extracellular loop (ECL2)
- High solubility in DMSO at 100 mg/mL
- Solid form storage at 4°C, protected from light
- In solvent storage at -80°C for 6 months or -20°C for 1 month, protected from light
- In vivo solubility options available for various formulations
Medchemexpress LLC Mecillinam (amdinocillin) | 32887-01-7 | 95.0% | C15H23N3O3S | 100 MG
Mecillinam (Amdinocillin) is a β-lactam antibiotic that demonstrates broad-spectrum activity against gram-negative organisms. It is intended for research use only.
- Broad-spectrum activity against gram-negative organisms
- Solid appearance
- White to off-white color
- Soluble in DMSO and H2O
- Storage at 4°C, protected from light, under nitrogen
Cayman Chemical CytochalasIn J 5mg
A deacetylated analog of cytochalasin H that weakly inhibits actin assembly but significantly alters mitotic spindle microtubule organization and kinetochore structure; suppresses the production of reactive oxygen species by stimulated human neutrophils
Cayman Chemical ANTIBODY GomIsIn C 5mg
Scavenges oxygen radicals and reduces the production of ROS by inhibiting neutrophil activity; attenuates respiratory burst in rat peripheral neutrophils via suppression of NADPH oxidase (39% inhibition at 30 UG/ml) and inhibition of cytosolic calcium release from intracellular stores (36% inhibition at 50 UG/ml)
Apexbio Technology LLC Ercalcidiol 21343-40-8 1mg
Ercalcidiol (CAS 21343-40-8) is a metabolite targeting vitamin D receptor (VDR)-like receptors It is involved in modulating mineral homeostasis by participating in the physiological regulation of calcium and phosphorus balance Ercalcidiol exerts its biological activity primarily through binding to VDR-related receptors In isolated perfused rat kidney experimental models Ercalcidiol is metabolized into several di- and tri-hydroxylated vitamin D2 derivatives supporting studies of vitamin D2 metabolism pathways Based on these pharmacological properties Ercalcidiol holds research potential for assessing vitamin D nutritional status and investigating vitamin D2 metabolism
Cayman Chemical 5 7-DIchlorokynurenIc AcId 5mg
An NMDA receptor antagonist (Ki = 40 nM in a radioligand binding assay); selectively selectively inhibits glycine- over kainate-induced NMDA currents at 15 μM in Xenopus oocytes expressing rat NMDA receptors; reduces NMDA-induced neurotoxicity in primary rat cortical neurons from 1 to 10 μM; reverses mechanical hyperalgesia in magnesium-deficient rats in a dose-dependent manner from 0.97-97 nmol; blocks the positive ionotropic effect, hypertension, and increase in myocardial oxygen demand induced by electrical stimulation of the PVN in anesthetized rabbits; increases social interaction time and time spent in the open arms of the elevated plus maze; disinhibits conflict responding in the Cook and Davidson conditioned conflict paradigm
Cayman Chemical ANTIBODY ALK-IN-1 5mg
A potent inhibitor of ALK (IC50 = 0.07 nM) that is less effective at IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively); drives cell death in (ALK+) Karpas-299 lymphoma cells with an IC50 value of 41.5 nM, while killing (ALK-) U937 cells with an IC50 value of 1,718 nM
Selleck Chemical LLC NL-1 S0767-10MG
The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor which induces a concentration-dependent decrease in cell viability with an IC50 of 47 35 M and 56 26 M in REH and REH/Ara-C cells respectively The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0 9 M and the Ki for NL-1 site 1 and site 2 was 4 78 and 2 77 respectively
Enzo Life Sciences (+)-Aphidicolin (1mg). CAS: 38966-21-1
Produced by Cephalosporium aphidicola and other fungi. A diterpene fungal metabolite that acts as reversible inhibitor of eukaryotic nuclear DNA replication. Useful for cell synchronization. Blocks the cell cycle at early S phase. Prolongs the half life of DNA methyltransferase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Acts synergistically with vincristine and doxorubicin. Apoptosis inhibitor/inducer. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (25mg/ml) or ethanol (25mg/ml). Long Term Storage: -20°C.
Medchemexpress LLC 17-Octadecynoic acid | 34450-18-5 | 98.0% | 280.45 | 5 MG
17-ODYA is a potent inhibitor of CYP450 ω-hydroxylase, specifically hindering the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids, and dihydroxyeicosatrienoic acids. It has demonstrated the ability to counteract isoproterenol-induced apoptosis and necrosis in cultured cardiomyocytes. Additionally, it functions as a click chemistry reagent due to its alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules.
- Inhibits ω-hydroxylase activity.
- Reduces formation of eicosanoids.
- Attenuates cell death in cardiomyocytes.
- Functions as a click chemistry reagent.
- Can be used for chemical reactions with azide groups.
- Has shown effects on renal function in rats.
- May offer cardioprotective benefits.
Cayman Chemical GSK 417651A 25mg
A TRPC3 and TRPC6 inhibitor (IC50 = ~0.4 µM for both); inhibits migration of isolated human fibroblastic valve interstitial cells into the wounded area in a scratch test assay at 2 µM
Medchemexpress LLC Mln120b | 783348-36-7 | C19H15ClN4O2 | 50 MG
MLN120B is a potent, ATP competitive, and orally active inhibitor of IKKβ with an IC50 of 60 nM. It inhibits multiple myeloma cell growth both in vitro and in vivo, and can also be used for research on rheumatoid arthritis.
- Potent, ATP competitive, and orally active IKKβ inhibitor.
- Inhibits multiple myeloma cell growth in vitro and in vivo.
- Suitable for rheumatoid arthritis research.
- High purity (99.76%).
- Appears as an off-white to light yellow solid.
- Soluble in DMSO (≥ 31 mg/mL).
- Inhibits phosphorylation and degradation of IκB.
- Blocks phosphorylation of p65 NF-κB.
- Reduces shuIL-6R, a tumor growth marker.
- Protects against arthritis-induced weight loss.
Cayman Chemical ANTIBODY BRD73954 10mg
A dual inhibitor of HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively); selective for HDAC6 and -8 over HDAC1-5, -7, and -9 (IC50s = 12, 9, 23, >33, >33, 13, and >33 µM, respectively); increases acetylation of α-tubulin in HeLa cells at 10 µM
Medchemexpress LLC Trans-cyclohexane-1,2-diol | 1460-57-7 | MFCD00066430 | 99.7% | 116.16 | 1 ML
Trans-cyclohexane-1,2-diol | 1460-57-7 | MFCD00066430 | 99.7% | 116.16 | 1 ML
Medchemexpress LLC GSK2879552 dihydrochloride | 1902123-72-1 | 99.8% | 437.40 | 1 ML
GSK2879552 dihydrochloride | 1902123-72-1 | 99.8% | 437.40 | 1 ML