Bioactive Small Molecules
Medchemexpress LLC HY-B0245 500mg , Busulfan CAS:55-98-1 Purity:>98%
HY-B0245 500mg Busulfan CAS: 55-98-1 Busulfan is a potent alkylator with selective immunosuppressive effect on bone marrow. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-B1161A 100mg , S-Methoprene CAS:65733-16-6 Purity:>98%
HY-B1161A 100mg S-Methoprene CAS: 65733-16-6 (S)-Methoprene is a juvenile hormone analogue that prohibits the ability of the insect to change from pupae to adult and is used as an insecticide. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Quinine sulfate hydrate | 6119-70-6 | 99.97% | 409.48 | 50 G
Quinine sulfate hydrate is an orally active alkaloid extracted from cinchona bark, primarily used in anti-malarial studies. It functions as a potassium channel inhibitor and has been shown to inhibit the proliferation and cytostatic effects of Dengue virus in HepG2 cell lines. Animal studies indicate a potential tumor-suppressing effect on skin cancer in Swiss albino mice, though it may also impact the antioxidant defense system.
- Orally active alkaloid from cinchona bark.
- Used in anti-malarial research.
- Acts as a potassium channel inhibitor.
- Inhibits DENV proliferation in HepG2 cells.
- Reduces viral DENV RNA and protein levels.
- Potential tumor-suppressing effect on skin cancer.
AdipoGen YM-254890, 568580-02-9, 1 mg
YM-254890 (1 mg), AdipoGen Life Sciences. Chemical. CAS: 568580-02-9. Formula: C46H69N7O15. MW: 960.1. Cyclic depsipeptide composed of unique amino acids differing from normal amino acids. Membrane permeable, potent and selective Galphaq family inhibitor. Inhibits the signal transduction of Galphaq, Galpha11 and Galpha14 (IC50=0.095M) by blocking the exchange of GDP for GTP, preventing the activation of the G protein. Galphaq signaling has been shown to regulate brown/beige adipocytes using the structurally similar specific Galphaq family inhibitor FR900359. It is suggested that inhibition of this pathway may be a novel therapeutic approach to combat obesity.
Apexbio Technology LLC EHT 1864(Synonyms: EHT-1864, EHT1864, RAC inhibitor EHT1864, Rac GTPase inhibitor EHT 1864), 10mg, CAS: 754240-09-0.
EHT 1864 (CAS 754240-09-0) is a small-molecule inhibitor targeting Rac family GTPases with strongest affinity and inhibitory activity toward Rac1 It interacts directly with Rac isoforms Rac1 Rac1b Rac2 and Rac3 exhibiting Kd values of approximately 40 nM 50 nM 60 nM and 250 nM respectively By disrupting nucleotide binding EHT 1864 blocks Rac1 activation and prevents the formation of active Rac1/PAK-RBD complexes thus inhibiting downstream cellular functions such as PDGF-stimulated lamellipodia formation and Rac1-mediated cellular transformation This compound serves as a valuable tool in cell biology research for studying Rac-dependent signaling pathways and cellular dynamics
Apexbio Technology LLC A-443654 552325-16-3 1mg
A-443654 (CAS 552325-16-3) is a potent selective small molecule inhibitor targeting all three Akt isoforms by binding the ATP pocket and reversibly inhibiting kinase activity (Ki 160 pM) It shows strong selectivity for Akt over other kinases and suppresses downstream substrate phosphorylation including GSK3 FOXO3 TSC2 mTOR 4EBP-1 and S6 In cellular assays A-443654 inhibits Akt activity and induces apoptosis or cell cycle arrest across cancer models with reported EC50 values of 100 nM (MiaPaCa-2) and 0 63 M (CLL cells) In in vivo xenograft models it significantly reduces tumor growth either as monotherapy or in combination with rapamycin A-443654 is widely applied in studies of PI3K/Akt signaling cancer progression and therapeutic response
Medchemexpress LLC Daporinad (FK866) | 658084-64-1 | 99.9% | C24H29N3O2 | 1 ML
Daporinad (FK866) is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), with a Ki value of 0.3 nM. It depletes NAD+ and ATP levels, inhibits mTORC1 and MAPK/ERK pathways, and activates TFEB to induce autophagy. Daporinad causes the depletion of the endoplasmic reticulum Ca²⁺ pool, ultimately weakening the mitogen-induced Ca²⁺ signal and the activation and function of T cells. Daporinad induces cell cycle arrest and apoptosis, and inhibits cell proliferation. It can be used for the study of myeloma, liver cancer, and immunosuppression.
- Non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt)
- Depletes NAD+ and ATP levels
- Inhibits mTORC1 and MAPK/ERK pathways
- Activates TFEB to induce autophagy
- Induces cell cycle arrest and apoptosis
- Inhibits cell proliferation
- Used for the study of myeloma, liver cancer, and immunosuppression
Medchemexpress LLC MPEP Hydrochloride | 219911-35-0 | 99.8% | 229.70 | 100 MG
MPEP Hydrochloride is a potent, selective, noncompetitive, orally and systemically active mGlu5 receptor antagonist. It effectively inhibits quisqualate-stimulated phosphoinositide (PI) hydrolysis with an IC50 of 36 nM, and demonstrates anxiolytic-like or antidepressant-like effects. Furthermore, MPEP Hydrochloride functions as a click chemistry reagent, featuring an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with Azide-containing molecules.
- Potent, selective, noncompetitive mGlu5 receptor antagonist.
- Orally active and systemically active.
- Exhibits anxiolytic-like or antidepressant-like effects.
- Functions as a click chemistry reagent with an alkyne group.
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions.
- IC50 of 36 nM for inhibiting quisqualate-stimulated PI hydrolysis.
Medchemexpress LLC LY-411575 | 209984-57-6 | 98.7% | C26H23F2N3O4 | 50 MG
LY-411575 is a potent γ-secretase inhibitor exhibiting high purity and significant inhibitory activity in both membrane-based and cell-based assays. It also effectively inhibits Notch S3 cleavage, making it suitable for various research applications.
- Potent gamma-secretase inhibitor with low nanomolar IC50 values.
- High purity of 98.68%.
- Effectively inhibits Notch S3 cleavage.
- Available in solid form for various research needs.
- Store powder at -20°C for 3 years or 4°C for 2 years.
- Store in solvent at -80°C for 2 years or -20°C for 1 year.
- Shipping at room temperature if less than 2 weeks.
Medchemexpress LLC (E)-Akt inhibitor-IV | 959841-49-7 | 98.6% | 614.54 | 1 ML
(E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor with potent cytotoxic properties. It is intended for research use only and is not sold to patients.
- Acts as a PI3K-Akt inhibitor
- Exhibits potent cytotoxic properties
- Shows an average GI20 of 0.04 μM on four cell lines including MDA-MB468, MDA-MB231, MCF7, and 184B5 cells
- Has little effect on the growth of 184B5 non-cancer cells at average GI20 doses
Medchemexpress LLC Elimusertib (BAY 1895344) | 1876467-74-1 | 99.7% | 375.43 | 100 MG
Elimusertib (BAY-1895344) is a potent, orally active, and selective ATR inhibitor with an IC50 of 7 nM. It demonstrates anti-tumor activity and is suitable for research into solid tumors and lymphomas.
- Potently inhibits proliferation of human tumor cell lines.
- Suppresses hydroxyurea-induced H2AX phosphorylation.
- Exhibits high selectivity against mTOR, DNA-PK, ATM, and PI3K.
- Shows potent antiproliferative activity against various cancer cell lines.
- Demonstrates potent anti-tumor efficacy in monotherapy in xenograft models of ovarian and colorectal cancer.
- Causes complete tumor remission in mantle cell lymphoma models.
- Has synergistic antitumor activity when combined with Carboplatin in platinum-resistant human CRC PDX models.
- Exhibits moderate oral bioavailability and short elimination half-lives.
Medchemexpress LLC L-Homocysteine | 6027-13-0 | 98.0% | 135.19 | 50 MG
L-Homocysteine is an amino acid with an L configuration, and an essential intermediate in the normal mammalian metabolism of methionine. It induces the upregulation of Cathepsin V, which mediates vascular endothelial inflammation in hyperhomocysteinaemia. This product is for research use only.
- Essential intermediate in methionine metabolism
- Induces upregulation of Cathepsin V
- Suitable for animal modeling to construct vascular endothelial inflammation models
Medchemexpress LLC Oxaloacetic acid (2-Oxosuccinic acid) | 328-42-7 | 99.9% | 132.07 | 10 MG
Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate that participates in various biochemical pathways, including the citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. This compound plays a role in facilitating the clearance of reactive oxygen species (ROS) and enhancing mitochondrial function.
- Metabolic intermediate
- Involved in citric acid cycle, gluconeogenesis, urea cycle, glyoxylate cycle, amino acid synthesis, and fatty acid synthesis
- Facilitates the clearance of reactive oxygen species (ROS)
- Improves mitochondrial function
- For research use only
- Appears as a white to off-white solid
- Endogenous metabolite